Are you looking for the best vitamin B12 supplement for you or your loved ones? If you have a specific condition or your diet is mostly vegetarian/vegan, this is supplementation to turn to!
In this article, we have reviewed the creme of the crop when it comes to vitamin B12 brands to help you make an informed decision. We included things such as the ingredients, the price, the content of B12, and more. In addition, we also created a comprehensive buyer’s guide to help you in your quest.
Now, let’s jump right to it!
The Best B12 Products in 2022We’re committed to providing you with the best products available. If you purchase through one of the links on our site, we may earn a commission. Read our full Affiliate Disclosure.
- High daily dose
- Manufactured in the US
- 3rd-party tested
- GMOs, dairy, & gluten-free
- US made in an FDA-compliant facility
- Non-GMO & vegan-friendly
- No unnecessary fillers
- Natural cherry flavoring
Best with MTHFR Support
- Suitable for vegans and vegetarians
- Allergen free
- Active forms of B12 and folate
- No artificial colors
- Whole-food formula
- Vegan and kosher-friendly
- No GMOs, dairy, soy, gluten, or nuts
- No preservatives
Best Chewable Option
- Ideal for vegans/vegeteranians
- Homocysteine metabolism support
- Variety of flavors
- Great methylcobalamin dose options
Best Sublingual Supplement
- USDA organic nutritional support
- GMO, gluten, dairy, & soy free
- Vegan liquid formula
- No animal testing
Best B12 Spray
- For people with MTHFR gene variants
- USDA Organic
- No dairy, nuts, gluten, and sugar
- Bariatric, celiac, and keto-friendly
Best USP Certified
- Certified non-GMO, vegan, and kosher
- Tested for 125+ herbicides and pesticides
- Certified Glyphosate residue free
- A mix of three essential vitamins
Best for Energy
- Best ratio of quality and price
- Sourced from top-notch ingredients
- No aftertaste
- Eco-friendly company
The Best Vitamin B12 Supplements in Detail
Now, let’s look at each product more closely and see what they have to offer. Here, you can see a detailed overview of the top B12 dietary supplements, ranked by quality, price, ingredients, shipping info, and more.
- Size: 2oz (60ml) bottle
- Type: Liquid
- Ingredients: 5000mcg of methylcobalamin, organic citrus extract
- Official Site Shipping & Returns: Free shipping & 365-day money-back guarantee
Live Conscious’s formula has a fresh citrusy flavor, but more importantly, it offers superior absorption and bioavailability of vitamin B12 — an essential nutrient that improves reproductive cells, boosts memory and supports the immune system.
In addition, this particular vegan formula contains 5000mcg of highly bioavailable methylcobalamin — the active form of the B12 vitamin — making it the best B12 option for vegans. Moreover, using it is relatively straightforward — just add 1ml of the product to an 8oz glass of water once per day for the best possible effect.
- + High daily dose
- + Manufactured in the US
- + 3rd-party tested
- + GMOs, dairy, & gluten-free
- − Requires a 10-fold dilution
- − Some complaints about energy levels not improving
- Size: 2oz (60ml) bottle
- Type: Liquid
- Ingredients: 3000mcg of methylcobalamin per serving, stevia, etc.
- Official Site Shipping & Returns: Free shipping & 90-day satisfaction guarantee
Seeing how the body cannot produce vitamin B12 on its own, the best source of this essential nutrient (other than food) can be found in its supplement form — or 3,000mcg of methylcobalamin (per serving) in SBR Nutrition’s case.
Additionally, what makes this one of the best options on our list is the liquid formula; it’s much easier on the digestive tract than capsules, for instance. Plus, there are no “filler” ingredients, again making it superior to capsules. What’s more, it’s completely vegan-friendly and doesn’t contain any GMOs, gluten, soy, etc.
- + US made in an FDA-compliant facility
- + Non-GMO & vegan-friendly
- + No unnecessary fillers
- + Natural cherry flavoring
- − Some users experience hyperactivation when taken in the afternoon
Best with MTHFR Support
- Size: 60 lozenges
- Type: Lozenges
- Ingredients: 1000mcg of vitamin B12 (80% as methylcobalamin and 20% as adenosylcobalamin); 1360mcg of folate
- Official Site Shipping & Returns: Free shipping & 60-day satisfaction guarantee
This Seeking Health formula contains both active B12 and L-5-methyltetrahydrofolate to aid the formation of red blood cells, boost nervous system operations and cognitive functions, as well as DNA biosynthesis. In addition, both ingredients increase the metabolism of homocysteine and help regulate energy levels.
Furthermore, the two active coenzyme forms of this top B12 supplement (methylcobalamin and adenosylcobalamin) are needed by certain B12-dependent enzymes, thus making it superior to your standard B12 supplement. Likewise, the active form of folic acid (L-5-MTHF) found in this product is the most prevalent form of folate in the blood.
And, if you want to lower your dosage, simply break the lozenge into smaller pieces. It was also veered as the best vitamin B12 supplement in 2020, and still holds strong in 2022.
- + Suitable for vegans and vegetarians
- + Allergen free
- + Active forms of B12 and folate
- + No artificial colors
- − It may interfere with sleep if taken in the afternoon
- Size: 30 vegan capsules
- Type: Capsules
- Ingredients: 1000mcg of methylcobalamin from the culture of S. cerevisiae
Continuously rated as the best raw, high-quality B12 supplement, Garden of Life Vitamin Code RAW B-12 is rich in 23 whole foods (an uncooked blend of fruits and vegetables), as well as other natural food cofactors. The technology behind the product comprises cold-production (below 46ºF) to ensure optimal freshness as each capsule contains live bacteria and enzymes.
Additional Vitamin Code RAW B-12 benefits include small, easy-to-swallow capsules and a whole food formula specially packed to maintain freshness. Moreover, it’s suitable for both vegetarians and vegans. Still, it’s worth noting that the company uses the same facility to manufacture other products that contain soy, dairy, peanut, tree nuts, and shellfish.
- + Whole-food formula
- + Vegan and kosher-friendly
- + No GMOs, dairy, soy, gluten, or nuts
- + No preservatives
- − Rigid shipping policy
Best Chewable Option
- Size: 60, 90, & 100 tablets
- Type: Chewable tablets
- Flavor: Lemon, Cherry, & Tropical
- Ingredients: 500mcg, 1000mcg, 2500mcg, 5000mcg of methylcobalamin
- Official Site Shipping & Returns: Free shipping on all orders & 60-day returns
With 500mcg to 5000mcg of methylcobalamin per tablet, the product ensures optimal absorption and the best possible dosage. Along with supporting energy production and brain function, the biologically active coenzyme form of B12 also supports homocysteine metabolism, which helps keep the bones strong and minimizes the risk of fractures.
Being one of the best vitamin B12 supplements it also helps regulate vital functions such as cell replication, production of red blood cells, and sleep-wake cycles. Lastly, methylcobalamin is considered superior to cyanocobalamin as it is kept in the body for longer, which is especially beneficial for vegetarians/vegans.
- + Ideal for vegans/vegeteranians
- + Homocysteine metabolism support
- + Variety of flavors
- + Great methylcobalamin dose options
- − The color of the product has different shades of pink
Best Sublingual Supplement
- Size: 1oz & 2oz
- Type: Sublingual liquid
- Ingredients: 2500mcg & 5000mcg - B12 blend — 80% methylcobalamin, 20% adenosylcobalamin; B12 tri-blend — 60% methylcobalamin, 20% adenosylcobalamin, and 20% hydroxocobalamin
- Official Site Shipping & Returns: Free shipping & one-year money-back guarantee
A whole plethora of customers are in love with this sublingual liquid B12, according to reviews. And despite the high price tag, one of the highest in the B12 supplements market, the product received mostly positive feedback.
What’s more, the ingredients will help boost energy levels naturally, improve brain health, and encourage restful sleep. Plus, there’s not one but two options — the regular and the tri-blend — to meet your specific needs. Overall, Global Healing produces a top-notch product that is both gentle and easy to absorb. Better yet, it’s made right here in the US in a state-of-the-art manufacturing facility.
- + USDA organic nutritional support
- + GMO, gluten, dairy, & soy free
- + Vegan liquid formula
- + No animal testing
- − Not the most affordable option around
Best B12 Spray
- Size: 1oz (30ml) bottle or 120 servings per container
- Type: Liquid spray
- Ingredients: 1500mcg of methylcobalamin per serving
- Official Site Shipping & Returns: Free shipping & 90-day returns
MaryRuth’s Methyl B12 Organic Liquid Spray does an exceptional job of boosting brain function and keeping the nerves and cells intact with its easy-to-use spray. Moreover, it’s also worth noting that this form of methylcobalamin is superior to synthetic cyanocobalamin when it comes to bioavailability.
In addition, the sweet berry taste contributes to the overall experience, which is simply excellent.
Last but not least, this formula is the optimal choice for people with MTHFR gene variants (almost 40% of us share it), ensuring high levels of energy and maintaining proper neuro and cognitive function. Likewise, this B12 vitamin supports DNA synthesis and red blood cell production.
- + For people with MTHFR gene variants
- + USDA Organic
- + No dairy, nuts, gluten, and sugar
- + Bariatric, celiac, and keto-friendly
- − Some customers may not like the steeper price tag
Best USP Certified
- Size: 90 tablets
- Type: Tablets
- Ingredients: 500mcg of methylcobalamin with S. cerevisiae, folate (L-5-MTHF with broccoli), vitamin B6 (pyridoxal-5-phosphate with organic brown rice)
- Shipping and returning policy: Free shipping; N/A
The MegaFood Methyl B12 Multivitamin contains all the necessary nutrients (the active form of vitamin B6 and the methylated forms of folate acid and B12) that aid the formation of red blood cells, improve heart health, and take care of the homeostasis of homocysteine.
Better yet, this quality B12 supplement is packed in an easy-to-swallow mini oval tablet that improves digestion and absorption. Most importantly, this product includes real food sourced from trusted family farms. Likewise, each vitamin is paired with its ideal whole food for maximum effect.
- + Certified non-GMO, vegan, and kosher
- + Tested for 125+ herbicides and pesticides
- + Certified Glyphosate residue free
- + A mix of three essential vitamins
- − Somewhat smaller dosage of B12
Best for Energy
- Size: 90 or 150 softgels
- Type: Softgels
- Ingredients: 1000mcg of cyanocobalamin
- Shipping and returning policy: N/A
Nature Made Vitamin B12 helps convert the food you eat into cellular energy while also supporting nervous system function and the proper forming of red blood cells.
Namely, the product provides you with a 90-day supply of 1000mcg of vitamin B12 that you consume with food and water. Interestingly enough, as this nutrient is mostly found in chicken (and meats in general), its supplement form is ideal for vegans or people who temporarily avoid dietary sources rich in vitamin B12.
And according to numerous pharmacists, this is the best B12 brand there is. It’s verified by the United States Pharmacopeia (USP) for one. Likewise, the manufacturer aims to remove any excess air and water used in order to reduce the carbon footprint of shipping and packaging.
- + Best ratio of quality and price
- + Sourced from top-notch ingredients
- + No aftertaste
- + Eco-friendly company
- − Cyanocobalamin and not methylcobalamin is used
Best for Improving Mood and Energy
- Size: 60 veggie capsules
- Type: Capsules
- Ingredients: 1500mcg of methylcobalamin
Doctor’s Best Fully Active B12 provides 1500mcg of the most biochemically active vitamin B12 — namely, methylcobalamin. As a result, it ensures all the major benefits of B12: improved memory, better mood, increased blood circulation, and overall well-being.
Also, as methylcobalamin is the most chemically complex of all the vitamins, its specific biochemical functions require sufficient quantities and reliable sources, such as Doctor’s Best Fully Active B12 for example. Overall, vitamin B12 is essential for regulating homocysteine levels. Otherwise, there’s an increased risk of cardiovascular issues and endothelial cell dysfunction.
- + Vegetarian and vegan friendly
- + Suitable for regular use
- + Gluten and soy-free, non-GMO
- + Energy and memory boosting
- − The 1500mcg dosage may be insufficient for people with deficiencies
- − Some customers complained about the slow dissolve
How to Choose Best B12 Supplementation
We prepared a comprehensive buyer’s guide to make it easier for you to select the very best supplement of vitamin B12 for your specific needs.
Hence, if you like what you hear, just keep on reading!
What Is B12?
Vitamin B12 is a water-soluble vitamin that plays a crucial role in the formation of red blood cells, cellular metabolism, nervous system function, and DNA production. Moreover, vitamin B12 cannot be produced in the body, and therefore must be obtained through various foods and supplements.
For instance, farm (animal) produce such as milk, cheese, eggs, meat (i.e., beef and poultry), and fish and seafood (i.e., mussels and crustaceans), as well as B12 vitamins found in supplements.
In addition, in order for our body to use vitamin B12, it has to be absorbed first. This is done in the stomach with the help of hydrochloric acid; the essential vitamin is first separated from food protein and is then absorbed by the intestines.
Hence, to obtain the recommended daily doses of vitamin B12, you should rely on animal-based diets or supplements. However, keep in mind that stomach problems may hinder the vitamin’s absorption rate even when you use the best B12 vitamin supplementation.
For example, people with chronic atrophic gastritis, gastrectomy (surgical removal of parts of the stomach), diseases of the terminal ileum (Crohn’s disease, lymphoma, resection, etc.), chronic alcoholism, AIDS, as well as long-term use of proton pump inhibitors or H2-receptor blockers.
If vitamin B12 deficiency remains untreated, it can lead to megaloblastic anemia, characterized by fatigue, muscle weakness, intestinal and stomach problems, nerve damage, and shifts in mood and proper cognitive function.
When to Consider Taking B12?
In the case you aren’t deficient in cobalamin, taking supplements won’t reap any additional benefits for your body. Namely, our body can store large amounts of vitamin B12. Hence, hypovitaminosis (or insufficient amounts of B12) is less common.
However, people who are primarily on a plant-based diet could greatly benefit from a vitamin B12 supplement. Moreover, older people, as well as those with diseases of the gastrointestinal tract (as previously mentioned), may have trouble absorbing the vitamin.
Therefore, before selecting a B12 vitamin for your specific diet, a blood test is recommended to determine the exact levels of vitamin B12 and B9 (folic acid) to rule out megaloblastic anemia.
Types of B12
Vitamin B12 supplements exist in both oral and injectable forms. Likewise, you can find over-the-counter products that can be sprayed into the nose, and sublingual pills are, naturally, dissolved under the tongue.
Nevertheless, it’s worth mentioning that there is still no evidence of greater absorption of sublingual types of B12 vitamin compared to its ingested counterparts; severe deficiencies of vitamin B12 are commonly treated with a shot though.
Besides, vitamin B12 could be found in nearly all multivitamins. To check the exact amount of vitamin B12 in the multivitamin formula, just read the product label.
Some foods can also be supplemented with vitamin B12, so be sure to check the label if you’re looking for foods enriched with B12.
Recommended Dosage of Vitamin B12
The recommended daily intake of vitamin B12 depends mostly on your age and gender.
For children, the recommended dosage is 0.4mcg for babies up to 6 months old, 0.5mcg for infants (7–12 months), 0.9mcg for toddlers (1–3 years), 1.2mcg for children (4–8 years), 1.8mcg for older children (9–13 years), and 2.4mcg for teens (14–18 years).
For adults, the required daily intake is about 2.4mcg. And for pregnant and breastfeeding women and teens — 2.6mcg and 2.8mcg, respectively.
For the best absorption, the form of vitamin B12 doesn’t matter as much. For instance, vitamin B12 found in dietary supplements is usually in the form of cyanocobalamin, which then converts into the active forms of methylcobalamin and 5-deoxy adenosylcobalamin. In addition, some supplements already contain methylcobalamin.
Also, it’s worth noting that despite some supplements containing vast amounts of vitamin B12, the absorption rate is limited by intrinsic factors, such as the body’s capacity to form a complex with vitamin B12. For instance, in healthy people, only 10mcg out of 500mcg is absorbed.
How to Safely Take the Most Effective B12 Supplement
Vitamin B12 supplements are relatively safe when consumed at recommended doses. And while adults are encouraged to take 2.4mcg of vitamin B12 per day (or more), your body can only consume the amount that the intrinsic factor allows; thus, any surplus will go into your urine.
Elevated serum levels of vitamin B12 may be the result of inappropriate vitamin replacement therapy, renal failure, some types of leukemia, metastatic cancer, acute and chronic hepatitis, cirrhosis, diabetes, obesity, etc. As such, extremely high doses of even the best B12 supplement methylcobalamin may result in dizziness, headaches, anxiety, nausea, and vomiting.
There’s also the possibility of having an allergic reaction to B12 supplements, which includes symptoms such as stomach pain, gas, and cramping; fatigue, vomiting, and diarrhea can also occur. In the event of a severe allergic reaction that leads to hives, breathing problems, or swelling of the face and tongue, a trip to the emergency room is strongly advised as these are potentially life-threatening.
Last but not least, some medications can affect the levels of vitamin B12, including anticonvulsants, metformin, oral contraceptives, some antibiotics, aminosalicylic acid, colchicine, proton pump inhibitors, vitamin C (ascorbic acid), etc.
Seeing how these medications can influence the absorption and bioavailability of even the best type of B12, your doctor should consider changing your prescriptions or lowering the dosage.
The Advantages and Disadvantages of Taking B12 Supplements
Some of the obvious disadvantages of vitamin B12 deficiency include fatigue, constipation, lack of appetite, loss of weight, and megaloblastic anemia. Nerve disorders can also arise, including memory and cognitive problems and pinching of the hands and feet. Likewise, depression, confusion, dementia, impaired memory, and mouth or tongue issues are also possible.
As previously mentioned, the benefits of taking vitamin B12 supplements include better memory, the formation of blood cells, proper nervous system function, etc.
Nevertheless, multiple B12 supplement reviews showed that vitamin B12, along with vitamin B9 (folic acid) and vitamin B6, does not alleviate the risk of cardiovascular disease or dementia.
Moreover, vitamin B12 supplements are frequently advertised to boost energy levels and athletic performance. Yet no study has found this to be the case, except for people with a vitamin B12 deficiency.
As vitamin B12 is crucial for our well-being and cannot be produced by our body, knowing what the best B12 vitamin options are is absolutely essential. Likewise, a vitamin B12 deficiency is not uncommon these days, seeing how veganism and vegetarianism are becoming more mainstream. In addition, some gastrointestinal conditions can also affect the vitamin’s absorption (as previously mentioned).
Which type of B12 is best?
It depends. Although cyanocobalamine can be better absorbed in the intestines than methylcobalamin, the latter has a higher retention rate. That said, in the case of B12 deficiency, both methylcobalamin and adenosylcobalamin should be used in order to yield the best possible results.
How much B12 should you take a day?
Albeit adults are encouraged to take 2.4 micrograms of vitamin B12 per day, they can safely take higher doses than that. This is because our body can only consume the amount it needs; any surplus B12 will go into your urine.
Also, it’s worth keeping in mind that absorption is limited to the amount of the intrinsic factor in the body. And lastly, taking extremely high doses can also lead to adverse effects.
What is the best time to take a B12?
Some guidelines recommend taking vitamin B12 twice per day — one capsule in the morning and one at night, separate from other medications and supplements to get all the benefits of vitamin B12.
However, due to the energy boost it provides, some people may experience discomfort at night; thus, they prefer taking it in the morning.
What is the best mcg of B12 to take?
Daily doses of 300mcg–10,000mcg of vitamin B12 are recommended in the case of deficiency. However, there is evidence that anywhere between 647mcg–1032mcg a day is the most optimal oral dosage.
In fact, different products provide different quantities of B12 — from 500mcg to 5000mcg. Some supplements are even enriched with other vitamins, such as folate.
Which form of vitamin B12 is best?
There are different forms of vitamin B12 supplements. The most common ones are oral tablets/capsules and sublingual drops/liquids. And seeing how the sublingual form dissolves under the tongue, it was widely considered the best for people with gastrointestinal diseases. Yet, this was never confirmed.
Lastly, in severe vitamin B12 deficiency cases, the best B12 supplement is given as an injection.